Kalkulačka tolerance Psilocybinu

Calculate your current psilocybin tolerance, find the right adjusted dose after recent use, or plan a microdose protocol with our free tolerance calculator. Supports cross-tolerance between psilocybin, LSD, mescaline, and DMT.

Track your psilocybin tolerance and find your adjusted dose. Enter your last dose and days since to see your current tolerance level, with a built-in microdose protocol planner (Fadiman & Stamets).

Quick Reference — Psilocybin tolerance decay timeline

Day 3

~50%

Day 7

~20%

Day 10

~10%

Day 14

~4%

Tolerance remaining after a standard dose. Based on exponential decay with ~3-day half-life.

Psilocybin Tolerance Decay Timeline

Based on 5-HT2A receptor downregulation. Standard dose (3g dried mushrooms). Individual results may vary.

Day	Tolerance	Status
Day 0	100%	Full tolerance — no effect from same dose
Day 1	80%	Minimal effect
Day 3	50%	Half tolerance
Day 5	32%	Noticeable reduction
Day 7	20%	Mostly reset
Day 10	10%	Nearly clear
Day 14	4%	Effectively zero

Cross-Tolerance Between Psychedelics

Classical psychedelics (psilocybin, LSD, mescaline) all primarily act on 5-HT2A receptors, which means tolerance to one creates cross-tolerance to the others. The degree varies: psilocybin and LSD share approximately 80% cross-tolerance, while mescaline shares about 60% with both. DMT is an exception — its rapid metabolism (effects last 15–30 minutes when smoked) means it causes minimal receptor downregulation and thus minimal cross-tolerance with other psychedelics.

From / To	Psilocybin	LSD	Mescaline	DMT
Psilocybin	100%	80%	60%	20%
LSD	80%	100%	60%	20%
Mescaline	60%	60%	100%	10%
DMT	20%	20%	10%	30%

Microdose Protocol Comparison

Comparison based on 0.15g psilocybin microdose over 30 days.

Protocol	Schedule	Frequency	Tolerance	Best for
Fadiman	1 day on, 2 days off	~2.3 doses/week	Minimal (<5%)	Most popular, well-researched
Stamets	4 days on, 3 days off	~4 doses/week	Moderate (10-15% by day 4)	Stacking with Lion's Mane + Niacin
Every other day	1 on, 1 off	~3.5 doses/week	Low (5-10%)	Simple schedule, good balance

Understanding Psilocybin Tolerance

Psilocybin tolerance is caused by the downregulation of 5-HT2A serotonin receptors after exposure to psychedelic compounds. When psilocin (the active metabolite of psilocybin) binds to these receptors, the brain responds by reducing receptor sensitivity and density. This is a protective mechanism that prevents overstimulation. The tolerance builds almost immediately after a dose and follows a predictable exponential decay pattern as receptors gradually return to baseline sensitivity.

Cross-Tolerance Between Psychedelics

Safety & Harm Reduction

Never increase your dose solely based on tolerance calculations. Individual sensitivity varies greatly. If you choose to use psychedelics with existing tolerance, start lower than the calculator suggests and wait to assess effects. Set and setting matter more than dose. Have a trip sitter for full doses. Do not combine with MAOIs, lithium, or other serotonergic medications. If you experience persistent psychological distress, seek professional help immediately.

Frequently Asked Questions

How long does psilocybin tolerance last?

Full tolerance after a standard dose (3g dried mushrooms) resets in about 14 days. The half-life is approximately 3 days, meaning tolerance drops to 50% after 3 days, 20% after 7 days, and less than 5% after 14 days. Larger doses may take slightly longer.

Is there cross-tolerance between LSD and shrooms?

Yes, both psilocybin mushrooms and LSD act primarily on 5-HT2A serotonin receptors. Cross-tolerance between them is approximately 80%, meaning if you took LSD recently, you'll need significantly more psilocybin for the same effects, and vice versa.

How do I calculate psilocybin tolerance?

Psilocybin tolerance follows exponential decay: 100% at day 0, approximately 50% at day 3, 20% at day 7, and less than 5% at day 14. The formula is: tolerance = 100% × e^(-days/4.33). Our calculator accounts for dose size and cross-tolerance between substances.

What is the Fadiman microdosing protocol?

Developed by Dr. James Fadiman, this is the most popular microdosing protocol: take a microdose on day 1, then rest for 2 days (days 2 and 3). Repeat this 3-day cycle. The rest days allow tolerance to fully reset between doses, keeping effects consistent.

What is the Stamets Stack?

Paul Stamets recommends combining psilocybin microdoses with Lion's Mane mushroom and Niacin (vitamin B3): 4 days on, 3 days off. The Lion's Mane supports neurogenesis, while Niacin helps distribution. Tolerance builds slightly during the 4-day on period but fully resets during the 3-day break.

Can I trip two days in a row?

You can, but the second trip will require roughly double the dose for similar effects due to rapid tolerance buildup. After a full dose, tolerance jumps to nearly 100% immediately. By day 2, it's still around 63%. Most experienced users recommend waiting at least 7 days between full doses for near-baseline effects.

How much more should I take if I have tolerance?

Use our dose adjuster mode. As a rough guide: at 50% tolerance you need 2× the dose, at 75% you need 4×, and at 90% you need 10×. We recommend against dosing above 80% tolerance as the required amounts become impractical and potentially unsafe.

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This calculator provides estimates based on published research on 5-HT2A receptor pharmacology. Individual responses to psychedelics vary significantly based on genetics, mental state, and environmental factors.

This tool is intended for harm reduction and educational purposes. Azarius does not encourage or condone the use of illegal substances. Check your local laws before using psychedelic substances.

Psilocybin-containing truffles are legal in the Netherlands. The legal status of psilocybin, LSD, mescaline, and DMT varies by country. This calculator does not constitute medical advice.